Ret Proto-Oncogene anticorps

N° du produit ABIN659065

Cet anticorps Souris Monoclonal détecte spécifiquement Ret Proto-Oncogene dans WB, IHC (p) et IF. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Ret Proto-Oncogene anticorps (ABIN659065)

Antigène: Ret Proto-Oncogene (RET)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ret Proto-Oncogene est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: 188CT11-2-3

Détail du produit anti-Ret Proto-Oncogene anticorps

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogène: This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.

Isotype: IgM kappa

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. WB: 1:500~16000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Ret Proto-Oncogene (ABIN659065)

Wang, Zhang, Gao, Fan, Chen, Liu, Meng, Zhao, Ma: "Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma." dans: Disease markers, Vol. 2016, pp. 6870470, (2016) (PubMed).

Détails sur Ret Proto-Oncogene

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: RET

Sujet: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Poids moléculaire: 124319

ID gène: 5979

NCBI Accession: NP_065681, NP_066124

UniProt: P07949

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation